TrIEM
TrIEM:
Leading products ICM-53 is in the early preclinical stage. ICM-53 could effectively control tumor growth with low toxicity in rodent studies. Combination with other immune checkpoint blockers further improved anti-tumor efficacy with low toxicity. IND-enabling studies of ICM-53 has been in progress.
- B7H3+ tumor targeted long-acting IL-15 superagonist
- Selectively stimulates proliferation of NK cells and CD8+ T cells in tumor
- Balanced activities of B7H3 binding and IL15
- Improved therapeutic index due to decreasing systemic IL15 exposure
- High production yield in stable CHO expression system
- High homogeneity and stability
- Aiming a safe dose similar to that of aB7H3 mAb, much higher than the conventional IL15-based immuno-cytokines
- More opportunities for drug combination strategies
- Broad market prospects: a wide range of indications of B7H3+ malignancy